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 πŸ”΄ GenRe-Mekong

πŸ”΄ GenRe-Mekong

Genetic Reconnaissance of Malaria in the Greater Mekong Subregion

GenRe-Mekong is a genetic surveillance project, aiming to provide National Malaria Control Programmes (NMCPs) in the Greater Mekong Subregion and other public health stakeholders with timely and actionable knowledge to support their decision-making in activities relevant to malaria elimination efforts.

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About this Site

GenRe-Mekong project supports control programmes and malaria research community through the sharing of data, tools and knowledge.

This site contains resources for all aspects of the GenRe-Mekong project, including open access genotyping data, technical resources for the grcMalaria R package, and guides to the Genetic Report Cards.

Data

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We routinely release genotype data, referred to as Genetic Report Card (GRC), to our partner studies, and periodically release public access datasets.

Tools

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We developed tools that turns rich information on the GRC datasheet into many types of genetic epidemiological maps.

Knowledge

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We share knowledge and provide trainings to expand in-country expertise, developing local capacity to evaluate drug resistance data and other genetic epidemiological outputs.

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Latest

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24 November 2025

GenRe-Mekong Scientific Forum 2025

The Annual Scientific Forum united 45 scientific experts and partner from six NMCPs for sharing insights and strengthening collaborative efforts toward a sustainable, evidence-based malaria elimination programme.

Highlights included P. vivax genetic epidemiology and innovative tools to support malaria elimination.

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20 May 2025 New GenRe-Mekong Study in Nature Comms

This paper give updates to the changes in antimalarial drug resistance epidemiology in the GMS, based on an analysis of 5982Β PfΒ dried blood spot samples collected by GenRe-Mekong from symptomatic patients in Cambodia, Laos, and Vietnam between 2017 and 2022, a period of time during which several NMCPs changed their malaria frontline treatment policies.

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What we do

GenRe-Mekong is a genetic surveillance project conceived to provide public health experts in the Greater Mekong Subregion and neighboring countries with timely and actionable knowledge, to support their decision-making in malaria elimination efforts. In partnership with National Malaria Control Programmes (NMCPs) and regional research studies, GenRe-Mekong collects and analyzes small dried blood spots samples from patients with symptomatic malaria, and uses high-throughput technologies to extract large amounts of parasite genetic information from each sample. The results are captured in Genetic Report Cards, which consist of datasets and reports regularly delivered to NMCPs to keep them abreast of rapid epidemiological changes in the parasite population.

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πŸ‘‹πŸΎ Meet our Core Team βž”

πŸ’› GenRe-Mekong is funded by

  • Gates Foundation
  • The Global Fund to Fight AIDS, Tuberculosis and Malaria
GenRe-Mekong project
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Prof Olivo Miotto, principal investigator of GenRe-Mekong project, gave an introduction and overview of the project.

⭐ Featured Publications

Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong SubregionGenetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion
Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion

Varanya Wasakul et al

2025

Nature Communications
www.nature.com
Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and eliminationGenetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Christopher G Jacob et al

2021

eLife
doi.org
Malaria outbreak in Laos driven by a selective sweep forΒ Plasmodium falciparum kelch13Β R539T mutants: a genetic epidemiology analysisMalaria outbreak in Laos driven by a selective sweep forΒ 
Malaria outbreak in Laos driven by a selective sweep forΒ Plasmodium falciparum kelch13Β R539T mutants: a genetic epidemiology analysis

Varanya Wasakul et al

2022

The Lancet Infectious Diseases
doi.org
Genetic Epidemiology Use Cases for Malaria Control Programmes: A MethodologyGenetic Epidemiology Use Cases for Malaria Control Programmes: A Methodology
Genetic Epidemiology Use Cases for Malaria Control Programmes: A Methodology

Olivo Miotto

2023

MalariaGEN
www.malariagen.net
Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysisIdentification of complex
Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis

Olivo Miotto et al

2024

The Lancet Microbe
www.thelancet.com
Pf7: An open dataset ofΒ Plasmodium falciparumΒ genome variation in 20,000 worldwide samplesPf7: An open dataset ofΒ 
Pf7: An open dataset ofΒ Plasmodium falciparumΒ genome variation in 20,000 worldwide samples

MalariaGEN

2023

Wellcome Open Research
doi.org
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Website developed and maintained by Varanya Wasakul, last updated: @Jan 7, 2026

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